Ozempic (semaglutide) is a medication used to treat type 2 diabetes and obesity. It is a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the action of GLP-1, a hormone produced in the gut that increases feelings of fullness and reduces appetite.
Ozempic is administered as a subcutaneous injection once weekly. The recommended starting dose is 0.25 mg once weekly for the first four weeks, followed by an increase to 0.5 mg once weekly. The maximum recommended dose is 1 mg once weekly1.
This dosing regimen has been shown to be effective in reducing blood sugar levels and promoting weight loss.
Dosing Instructions
Before starting Ozempic, it’s important to consult with a healthcare provider to determine the appropriate dosing regimen. The healthcare provider will consider factors such as age, weight, medical history, and other medications being taken.
The first dose of Ozempic should be administered as a subcutaneous injection in the abdomen, thigh, or upper arm. The recommended starting dose of 0.25 mg should be taken once weekly for the first four weeks. After the initial four weeks, the dosage is then increased to 0.5 mg once weekly. If an adequate reduction in blood sugar levels or weight loss is not achieved after 12 weeks of treatment with the 0.5 mg dose, the dosage can be increased to 1 mg once weekly1.
Ozempic should not be administered more than once a week, and the injection site should be rotated with each administration to prevent injection site reactions.
Dosage Adjustment
Dosage adjustments may be necessary for individuals with renal or hepatic impairment. In patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²) or end-stage renal disease, the starting dose should be lowered to 0.25 mg once weekly, and the maximum dose is 0.5 mg once weekly1.
In patients with hepatic impairment, no dosage adjustment is necessary1.
Missed Dose
If a dose of Ozempic is missed, it should be administered as soon as possible. If the next scheduled dose is less than two days away, wait until the next scheduled dose and resume regular dosing1.
Dosage Forms and Strengths
Ozempic is available in prefilled pens containing semaglutide.
The pens are available in the following doses2:
- 0.25 mg/0.5 mL
- 0.5 mg/0.5 mL
- 1 mg/0.5 mL
The pen should be inspected visually for particulate matter and discoloration prior to administration. The medication should not be used if there are signs of particulate matter or discoloration in the pen1.
Conclusion
Ozempic is a medication that is administered as a subcutaneous injection once weekly to treat type 2 diabetes and obesity. The recommended starting dose is 0.25 mg once weekly for the first four weeks, followed by an increase to 0.5 mg once weekly. The dosing regimen may be adjusted based on factors such as age, weight, and medical history.
It’s important to consult with a healthcare provider before starting Ozempic and to follow the dosing instructions carefully. With proper administration and adherence, Ozempic has the potential to improve blood sugar control and promote weight loss in individuals with type 2 diabetes and obesity.
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